Evaluating linkage and linkage disequilibrium: use of excess sharing and transmission disequilibrium methods in affected sib pairs
نویسندگان
چکیده
منابع مشابه
The Pattern of Linkage Disequilibrium in Livestock Genome
Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...
متن کاملMultilocus linkage analysis of affected sib pairs.
OBJECTIVE The conventional affected sib pair methods evaluate the linkage information at a locus by considering only marginal information. We describe a multilocus linkage method that uses both the marginal information and information derived from the possible interactions among several disease loci, thereby increasing the significance of loci with modest effects. METHODS Our method is based ...
متن کاملEstimating and testing linkage disequilibrium from sib data
We consider estimation and testing of linkage equilibrium from genotypic data on a random sample of sibs, such as monozygotic and dizygotic twins. We compute the maximum likelihood estimator with an EM-algorithm and a likelihood ratio statistic that takes the family structure into account. As we are interested in applying this to twin data we also allow observations on single children, so that ...
متن کاملInference of Identity-by-Descent in Sib Pairs: Analysis with and without Linkage Disequilibrium
In gene mapping, after an initial genome-wide linkage scan, the next step often involves candidate region studies or fine mapping using dense markers. Dense genotyping, however, introduces linkage disequilibrium (LD). Traditional linkage analysis assuming no LD leads to increased false positive rates. Hence, we develop models to incorporate linkage disequilibrium, focusing on the sib pair desig...
متن کاملMaximum likelihood estimation of linkage disequilibrium in half-sib families.
Maximum likelihood methods for the estimation of linkage disequilibrium between biallelic DNA-markers in half-sib families (half-sib method) are developed for single and multifamily situations. Monte Carlo computer simulations were carried out for a variety of scenarios regarding sire genotypes, linkage disequilibrium, recombination fraction, family size, and number of families. A double hetero...
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ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 2000
ISSN: 0003-4800,1469-1809
DOI: 10.1046/j.1469-1809.2000.6450419.x